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恶性肿瘤患者血清自然杀伤细胞抑制因子的观察
Serum natural killer cell suppressive factor in the patients with malignant tumors
【摘要】 观察了20例恶性肿瘤患者血清对正常人自然杀伤细胞(NKC)活性的影响,发现荷瘤者血清可使正常人NKC活性明显抑制,其抑制率达78.9%,伴转移癌患者血清的抑制率明显高于不伴转移者。同时证实,癌症患者血清NKC抑制因子活性可被消炎痛部分阻断,而一定剂量的白细胞介素-2则无明显阻断作用,提示癌症患者血清存在的NKC抑制因子与肿瘤的发生发展密切相关,其本质可能是多因素的。
【Abstract】 The influece of serum in 80 malignant tumors cases to natural killer cell (NKC) activity of normal controls was studied.The results showed serum of tumor-bearing patients sup pressed 78. 9% of normal control NKC activity. This serum suppressive activity in the patients with matastatic tumors were apparently higher than those without - metastases. Otherwise,this suppressive activity could be partly blocked by in domethacin, hut not by smalll dose recombinant interleukin2. So it may suggest that serum NKC suppressive factor in tumor - bearing patients was closely related with developing and advancing of malignant tumors, however it’s essence might might be multifarious.
【Key words】 Neoplasm; Natural killer cell; Immune suppressive factor; Indomethacin; Interleukin-2;
- 【文献出处】 现代实用医学 ,Modern Practical Medicine , 编辑部邮箱 ,1997年03期
- 【分类号】R730.43
- 【被引频次】1
- 【下载频次】15