【摘要】 应用荧光偏振免疫法(FPIA)对274例肾移植术后患者行2312人次全血环孢素A(CsA)浓度测定。结果分析表明:(1)CsA在三联免疫抑制疗法中的理想治疗窗浓度范围是:术后第1、2、3和4～12个月全血CsA浓度分别为300～430、280～350、180～280和110～250ng/ml;(2)FPIA法具有快速、准确、操作简便,适于批量测定等优点。讨论了肝肾中毒、排斥反应、高危人群及合并用药与全血CsA浓度的关系。更多还原

【Abstract】 Whole blood concentration of CsA was assayed 2312 times in 274 renal transplant recipientsby the fluorescence polarization immunoassay (FPIA, abbott TDx). In the 1st, 2nd, 3rd and 4~12 th month post kidney transplantation) the ideal therapeutic window range of whole blood CsA level was 300~430,280 ~350,180~280 and 110-250 ng/ml respectively for patients on triple immuno-suppressive therapy. FPIA is precise, Sensitive, rapid and easy to carry out. The correlation between hepatotoxcity. nephrotoxcity of CsA, rejection, old and risk recipients and whole blood CsA level was discussed.更多还原