【摘要】 采用一组单克隆抗体(T₁₆、M₃₄₄、T₁₃₈、T₄₃),用APAAP免疫细胞化学方法,对63例膀胱移行细胞癌及10例非肿瘤患者的膀胱冲洗液作了研究。T₃₅在全部63份标本呈阳性。随着肿瘤分期、分级的升高,以及肿瘤的复发,M₃₄₄阳性率降低,T₁₃₈及T₄₃阳性率升高。尿细胞学检查联合应用,可弥补相互间的不足,使肿瘤检出率进一步提高。M₃₄₄、T₁₃₈及T₄₃MAb可作为膀胱肿瘤早期诊断恶性程度及复发的评估指标。更多还原

【Abstract】 Using a panel of four monoclonal antibodies (T16, M341,T138,T43). .n immunocytochemical (APAAP)study of bladder washings was carried out in 63 cases of transitional cell carcinoma and 10 of non-tumor patients. T16 was positive in all of 63 cases. With the elevation of stage and grade of bladder tumor, the positive rate of M344 was decreased and T138,T43 was increased. The three MAb had a corresponding relation to the tumor recurrence. Combining urine cytology and MAb can increase the detecting rate of bladder tumor. The results indicated that the positivity of M344, T138 and T43 was closely related to stage, grade and prognosis. It can be used as evaluating marker of malignant degree, recurrence and early diagnosis. transitional cell carcinoma of the bladder; monoclonal antibody; urine cytology; immunocytochemistry更多还原