【摘要】 目的：为了探讨内皮素－1（ET－1）在急性心肌梗塞（AMI）病人中的作用及临床意义。方法：采用放射免疫分析法动态测定35例AMI病人血浆ET－1和肿瘤坏死因子（TNF）的含量，并与心肌酶（CPK－MB）浓度做相关分析。结果：AMI病人血浆ET－1水平较对照组显著升高（100．55±22．50ng/LVS58．7±11．62ng/L）6小时后达高峰，随后缓慢降低，直至7日仍比正常值高，溶栓组比非溶栓组血浆ET－1下降快，入院后72小时已降至正常。ET－1与血清TNF－α呈正相关性（r=0．509，P＜0．05），与CPK－MB则无明显相关性。结论：血浆ET－1在AMI的发病中起一定的作用，测定ET－1水平有助于判断病情变化及预后。更多还原

【Abstract】 To explore the effect and clinical significance of endothelin-1 (ET-1) upon acute myocardiac infarction (AMI ) patients. Method: Adopt radioimmunoassay to dynamically determine the contents of plasma endothelin - 1 and tumor necrosis factor (TNF) in 35 cases of acute cardiac infarction patients, and take the relative analysis with myocardial enzyme (CPK- MB) concentration.Result: The ET-1 level in the plasma of the AMI patients is notably raised against that of the control group (100. 55±22.05ng/L vs 58.7 ± 11 .62ng/L) and reached the peakvalue in 6 hoars,then slowly reduced but still were higher than the normal value after 7 days. The plasma ET- 1 of the thrombolysis group decreased faster than that of the nonthrombolysis group, it resumed normal 72 hours after the patients being hospitalized. The ET-1 and serum TNF- αshowed a positive interrelationship (r = 0. 509, P < 0. 05 ),but there exists no marked interrelation between the endothelin and the CPK- MB. Conclusion:The serum ET-1 plays acertain role in the invasion of AMI, as determining the ET - 1level would be conductive to the judgement on the changing state of illness as well as the prognesis.更多还原