【摘要】 目的：探讨ｐ５３蛋白和增殖细胞核抗原（ＰＣＮＡ）在人喉鳞状细胞癌的表达。方法：应用免疫组织化学Ｓ－Ｐ法对８０例喉鳞状细胞癌、１０例声带息肉、１０例喉乳头状瘤进行检测。结果：（１）ｐ５３蛋白在喉鳞状细胞癌阳性率为４１％，阳性细胞指数（ｘ±ｓ％）为５４．５９±２２．８２，与临床Ｔ分期，分化程度以及淋巴结转移无关；（２）ＰＣＮＡ指数在声带息肉，喉乳头状瘤，喉鳞癌中逐渐提高，在有淋巴结转移的比无淋巴结转移的指数明显增高（Ｐ＜０．０１）。结论：ＰＣＮＡ指数对判断喉鳞癌患者的预后有一定价值。更多还原

【Abstract】 Purposes To study the expression of p53 protein and proliferating cell nuclear antigen (PCNA) in laryngeal squamous carcinoma (LSC).Methods 80 cases of LSC and 10 cases of laryngeal polyp and 10 cases of laryngeal papilloma were investigated by immunohistochemical S P technique.Results (1) The positivity rate of p53 in LSC was 41% and the index of positive cell was 54 59±22 82, which were not related with T staging,histological grading and the lymph node metastasis of LSC.(2) The index of PCNA was the highest in LSC and the lowest in vocal polyp.The index in the patients with lymph metastases was significantly higher than that in those without metastases( P <0 01).Conclusions The index of PCNA is helpful for predicting the prognosis in LSC.更多还原