【摘要】 目的探讨糖尿病视网膜病变发生发展的有关因素。对40例糖尿病机网膜病变患者红细胞膜Ca²⁺－Mg²⁺－ATPasc活性进行了检测，并与红细胞内Ca²⁺－Ms²⁺－ATPasc含量、空腹血糖、糖基化血红蛋白及红细胞变形指数等进行了分析。结果糖尿病机网膜病变患者红细胞膜Ca²⁺－Ms²⁺－ATPasc活性显著下降（P＜0．01），细胞内Ca²⁺含量增加（P＜0．01）而Mg²⁺含量则显著下降（P＜0．01）。糖尿病视网膜病变者红细胞膜Ca²⁺－Ms²⁺－ATPasc活性下降与空腹血糖、糖基化血红蛋白、红细胞变形指数及红细胞内Ca²⁺－Ms²⁺－ATPasc含量等变化密切相关。结论糖尿病视网膜病变患者红细胞膜Ca²⁺－Ms²⁺－ATPasc活性异常下降可能是导致或加速视网膜病变发生发展的原因之一。更多还原

【Abstract】 To study the correlative factor about the occurrence and development of diabetic retinopathy（DR）. Methods Ca²⁺-Mg²⁺-ATPase activity in ery-throcyte membrane was investigated in 40 Patients with DR. The relation of Ca²⁺-Mg²⁺-ATPase activity with content Ca2+ and Mg2+ in erythrocyte, fasting biood -glucoae （FBG ）, hemoglobin glycosylation （HBAlc ）, and erythrocythe filterability index （EFI）was also studied.Results Ca²⁺-Mg²⁺-ATPase activity in reythrocyte membrane was singnificantly decreased in DR （P <0. 01 ）. The defect was acconipaned by, an increase in erythrocyte Ca2t （P < 0.01 ）2nd a decrease in erytho-cyte Mg’+ （P <0. 01）. The decrease of Ca²⁺-Mg²⁺-ATPase activity in erythrocyte in DR was connected with the cllanges of FBG, HbAlc, EFI, and the content of Ca2+ and Mg2+ in erythrocyte. Conclusiou The de-crease of Ca²⁺-Mg²⁺-ATPase activity in erythrocyte membrane may contribute to the occurrence and devel-opment of DR.更多还原