【摘要】 调查３３例双相情感性精神障碍患者迟发性运动障碍（ＴＤ）有关的因素，并评估其认知功能。用迟发性运动障碍量表（Ｓｉｍｐｓｏｎ量表）、认知功能问卷调查，并收集临床资料。结果发现，有ＴＤ的比无ＴＤ的患者住院总次数多，因躁狂发作住院的次数多，抗精神病药治疗时间长，平均日剂量高，合并抗胆碱能药时间长。表明长期、高剂量抗精神病药治疗可能是双相情感性精神障碍病人ＴＤ产生的高危因素，且长期并用抗胆碱能药增加ＴＤ产生的危险。有无ＴＤ的病人认知功能并无差异。更多还原

【Abstract】 Objective:To investigate the risk factors associated with tardive dyskinesia(TD)in patients with bipolar affective disorder.Method:33 patients who met the CCMD-2-R criteria for diagnosis of bipolar affective disorder were assessed with The Tardive Dyskinesia Scale and Cognitive Function Questionnaire.Other clinical data were also collected.Results:There was no significant difference between TD and non TD subjects in the number of major affective episoders cognitive function,and previous lithium or carbamazepine treatment TD patients had more hospital admissions,were more frequently admitted for mania,showed longer exposure to neuroleptics and anticholinergic and received a higher mean dose of neuroleptics.Discussion:Long term and high dose neuroleptics treatment are high risk factors for TD in bipolar patients.Concurrent use of anticholinergic agents increases the risk of developing TD.更多还原