【摘要】 本文应用免疫组织化学技术,对110dBSPL 白噪声连续刺激3h 后豚鼠耳蜗内热休克蛋白72(HSP72)的表达进行了研究。结果发现声损伤后耳聋的豚鼠耳蜗三排外毛细胞HSP72呈阳性表达,正常对照豚鼠耳蜗未见阳性表达。认为热休克蛋白参与声损伤时耳蜗的应激反应,可能对毛细胞具有保护作用。更多还原

【Abstract】 Using the immunohistochemical technique we studied the expression of HSP72 in guinea pig cochlea after three-hour continuous stimulation of 110dB SPL white noise.The results showed that the expression of HSP72 was positive staining in all three rows of outer hair cells of the noise- damaged cochlea,whereas It was negative in nornal controls.The heat shock protein is involved in a stress response of the cochlea to acoustic trauma.It may play a role in the protection of hair cells.更多还原