【摘要】 本实验旨在研究硫酸软骨素蛋白多糖与牙周炎的相关性。采用免疫组织化学方法,对牙周炎引起的硫酸软骨素蛋白多糖变化进行研究。结果显示硫酸软骨素(DS、C4S、C6S)广泛分布于上皮下结缔组织、牙周韧带和血管周围,在牙槽骨局限于哈佛氏管和骨小腔内壁。牙周炎时随着组织溶解破坏,其染色反应减弱消失,说明硫酸软骨素是牙周组织的基本成分,与牙周炎关系密切。更多还原

【Abstract】 This study was designed to investigate the immuohisto - chemical localization of chondroitin sulfate isomers of proteoglycans (PG) in human healthy periodontal tissue and adult periodontitis, by using monochonal antibodes (2 - B - 6,3- B - 3). The results demonstrated that chondroitin sulfate was widespread in gingival connective tissue and periodontal membrans and peripheral blood vessels. In alveolar bone chondroitin-4 sulfate,chordroitin-6 sulfate and dermatan sulfate-PG were found inside the Haversian canals and lacunae. As destruction of gingival connective tissue occurs,the three chondroitin sulfate - PG were stained weakly. These findings suggested that chondroitin sulfate PG may be degraded by inflammation in gingival connective tissue and may play an important role in bone resorption.更多还原