【摘要】 应用放射免疫方法，测定了２０例正常孕妇血清Ｐ物质水平，并以１２例正常非孕妇女作为对照组进行比较。测定结果表明，妊娠期妇女血清Ｐ物质含量为（１４５．１±２４．８）ｐｇ／ｍｌ，而非妊娠妇女血清Ｐ物质含量为（４６５．４±５９．５）ｐｇ／ｍｌ，两组比较有显著性差异（Ｐ＜０．０１），即妊娠期妇女血清Ｐ物质水平明显低于非妊娠期妇女血清Ｐ物质水平。提示：妊娠期妇女血中雌孕激素水平明显升高，可能对Ｐ物质的分泌有负反馈抑制作用。更多还原

【Abstract】 The serum levels of substance P were tested in 20 normal pregnant women and compared with those tested in 12 normal no pregnant women,using radioimmunoassay.The results showed that the content of serum substance P in pregnant women was(145 1±24 8)pg/ml while that in no-pregnant women was(465 4±59 5)pg/ml. The difference was obviously significant ( P <0 01).Our results suggest that the increase of serum levels of estrogen and progestogen might play a feedback inhibitory role in the secretion of substance P.更多还原