【摘要】 酿酒酵母（Saccharomycescerevisiae）YBD101菌株的类金属硫蛋白能清除羟基自由基。含类金属硫蛋白的活性的干酵母饲喂7个半月龄昆明小鼠，可提高肝中SOD活性（p＜0．01），降低LPO含量（p＜0．01），对脑中MAO－B活性有一定抑制作用（p＜0．01），对肝中MAO－B活性几乎不抑制。含类Cu－MT活性干酵母对上述衰老有关三项生化指标的作用，与免肝Zn-MT纯品效果一致。提示酵母菌类Cu－MT在预防衰老和保护人体健康方面有良好的应用前景。更多还原

【Abstract】 Antioxidation of Xiccharomyces cerevisiae YBD101 CU-metallothionein was investigated. The results indicated that the YBD101 Cu-metallothionein could scavenge hydroxyl radicals. It was shown that this containing active Cu-metallotheonein of frozen cells could increase the acivity of SOD and decrease the content of LPO in liver of treated ageing mice. It was also observed that this Cu-metallothionein could inhibit the activity of MAO-B in brain, but it was not been observed that this Cu-metallodrionein could affect positively the change of activity of MAO-B in liver.Effects of yeast Cu-MT on antioxidation were as good as that of rabbit liver Zn-MT.It suggests that there is a promising prospect for applying YBD101 Cu-metallothionein to preclude ageing and to protect health.更多还原