【摘要】 研究了甾族化合物的结构与抗炎活性相关性的三维构效关系，采用比较分子力场分析法（CoMFA）寻找结构与活性的关系，建立了一个可靠的构效关系模型，为活性分子的进一步修饰和改造提供了信息。更多还原

【Abstract】 Comparative molecular field analysis (CoMFA) is applitd in the correlationof some steroids and their antiinflammatory activities. The comparison of CoMFA resultswith different alttice spacing and atom probes are investigated. CoMFA resulted in a quantitative description of the major steric and electrostatic field effects. which provides valuableinformation for the design of steroids with higher antiinflammatory activities.更多还原