【摘要】 用雄性大鼠6只.一次性腹腔注射V_D60万单位/kg体重,存活35天(诱发动脉粥样硬化)后,取下丘脑作石蜡连续切片,用体视学方法分析了下丘脑弓状核和视前内侧区神经元的形态参数变化.结果发现:下丘脑区两个核团的神经元体积变小,数目增多,发生了明显的形态学改变.胸、腹王动脉弹性膜断裂,平滑肌细胞增生,形成明显的动脉粥样斑块.文内对其它形态参数也进行了比较和分析.更多还原

【Abstract】 Twelve male rats weighing 200-250 g were used. They were divided into two groups. The experimental group was given intraperitoneal injection of vitamin D( 600,000 IU/kg) and the control group was given the equal volume of water. After surviving for 35 days the animals were killed and slides of their hypothalamus were made and stained with Nissl method. The morphological changes in the neurons of the arcuate nucleus and the medial preoptic area of rats in the two groups were analysed morphometrically. The results were as follows : The number of neurons in the above mentioned two nuclei showed significant increase in the experimental group when compared with those of the controls, but the average volume of the neurons was smaller than that of the control group. Atherosclerosis was marked by the rupture of elastic laminae, smooth muscle cell proliferation and atherosclerotic plaque formation of the wall of the thoracic and abdominal aorta. The results indicated that there were remarkable morphological changes in the arcuate nucleus and the medial preoptic area of atherosclerotic rats, which might be of significance in the development of atherosclerosis.更多还原