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兔局灶脑缺血后脑片[Ca²⁺]i的变化

THE CHANGE OF [Ca²⁺]i AFTER MCAo ISCHEMA IN RABBIT

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【Author】 Zhao Weiguo;Sun Qingfang;Zhang Tianxi;et al.( Dapartment of Neurosurgery, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025 )

【机构】上海第二医科大学瑞金医院神经外科!上海； 200025；河北医学院附属四院神经外科；

【摘要】目的：研究脑缺血后脑片[Ca2＋]i变化。方法：采用新型Ca2＋荧光指示剂Fura－2双波长法测定兔大脑中动脉阻塞（MCAo）局灶脑缺血后脑片细胞内游离钙（[Ca2＋]i）。结果：脑缺血后脑组织[Ca2＋]i显著升高。结论：[Ca2＋]i在脑缺血损害中起重要作用。更多还原

【Abstract】 Aim: To study the changes of [Ca2+]i on brain slice after MCAo ischemia. Methods: The [Ca2+]i level was determined by new type Ca2+indicator-Fura-2/AM with double-wave length. Results: The [Ca2+]i was significantly increased after focal cerebral ischemia. Conclusion: These results suggested that [Ca2+]i increase after cerebral ischemia, which plays an important role in the damage to the ischemic brain tissue.更多还原