【摘要】 本研究采集750例妊娠妇女按自愿选择终止早孕的方法,比较药物(组Ⅰ、Ⅱ)与吸宫(组Ⅲ)的安全性、有效性、可接受性。三组治疗方案:①米非司酮首剂50mg,之后25mg/12h×4+PG05 1mg阴道塞药(组Ⅰ);②米非司酮同前+米索600μg(组Ⅱ);③吸宫流产(组Ⅲ)。结果显示:药流组与吸宫组完全流产率分别为94.2％(476/500)、100％(250/250),两组有显著性差异(P<0.001);不全流产率、失败率三个组分别为:2.4％和0、3.4％和0,组间有明显差异(P<0.01);出血量比月经量增多的对象占19.2％和10％,明显增多的占1.4％和0,组间有显著差异(P<0.05);出血持续时间为11.0±7.1和4.8±3.1,组间有显著差异(P<0.01);转经时间两种流产无统计学意义;两种流产的副反应,药流组的眩晕、下腹痛发生率高于手术组,而恶心、呕吐发生率低于手术组,两组间有显著性差异(P<0.01);对此次流产表示满意的药流组和吸宫组为:79.6％和84.4％,两组中分别有86.4％以及64.0％的对象在下一次发生意外妊娠时,仍然愿意采用本次选择的方法终止早孕。结果提示两种流产仍是目前终止早孕的最佳方法,药物流产作为终止早孕方法的补充是安全,有效、可接受的。更多还原

【Abstract】 This study compared efficency acceptability and side effects of Mifepristone combined with Misoprostol and PG05 for termination of early pregnancy and surgical abortion. 750 volunteers were randomly divided into three groups. 50mg of Mifepristone initial dose, followed 25mg 12h for 4 dose plus suppository PG05 lmg( Group I) or plus Misoprostol 600ug( Group Ⅱ), and surgical abortion(Group Ⅲ) .The results showed that the total, complete abortion rates for these three groups were 94. 2% (476/500 Group I, Ⅱ), 100% (250/250 Group Ⅲ) respectively. There were significant differences (P < 0. 001 ). Incomplete abortion rates and failure rateswere2 . 4 % ( Group I, Ⅱ) , 0 ( Group Ⅲ) ; 3. 4%(Group I,Ⅱ),0(Group Ⅲ)respectively, there were differences in three groups (P < 0. 01) ; vaginal bleeding increased more than menses: 19.2% (Group I, Ⅱ), 10% (Group Ⅲ);increase significantly, 1.4%. The duration of vaginal bleeding 11. 0 ± 7.1 and 4. 8 ± 3.1(P<0. 01), there were significant differences. Side effects: the incidence of dizziness and lower abd. Pain were higher in group I, Ⅱ, however, narsea and vomiting were lower than comparing with in group Ⅲ(P<0.01).The rates of satisfaction were 84.4% (Group, Ⅲ),79.6%(Group I, Ⅱ) respectively. Thus, the results indicated that the two methods were the best selection for termination of early pregnancy.更多还原