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[trans-en₂O_s（η-H₂）]²⁺ as an ¹H NMR probe for the coordination of some anticancer metal complexes to deoxyguanotide

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【Author】 YANG Pin,GUO Maolin(Institute of Molecular Science,Shanxi University,Taiyuan 030006,China)LI Qingshan,TIAN Yanni(State Key Laboratory of Coordination Chemistry,Nanjing University,Nanjing 210093,China)Zai-Wei LI and Henry TAUBE(Department of Chemistry,Stanford University,Stanford,CA 94305,USA)

【机构】 Institute of Molecular Science； Shanxi University； Taiyuan 030006； China； State Key Laboratory of Coordination Chemistry； Nanjing University； Nanjing 210093； Department of Chemistry； Stanford University； Stanford； CA 94305； USA；

【摘要】 <正> The molecular hydrogen complex of osmium,[trans-en2Os(η-H2)]2+(en,entlylendediamine) is a new 1H NMR recognition probe for biomolecules.By using this probe,the coordination between deoxyguanylic acid (dGMP) and four metal anticancer complexes,titanocene dichloride,(C2H5)2SnCl2(phen),(C2H5)2SnCl2 and cis-piatm are studied in D2O under the condition near the physiological one.The results show that the former three complexes mainly and strongly coordinate with the phosphate oxygen of dGMP,while cisplatin mainly coordinates with N(7) of dGMP更多还原

【Abstract】 The molecular hydrogen complex of osmium,[trans-en2Os(η-H2)]2+(en,entlylendediamine) is a new 1H NMR recognition probe for biomolecules.By using this probe,the coordination between deoxyguanylic acid (dGMP) and four metal anticancer complexes,titanocene dichloride,(C2H5)2SnCl2(phen),(C2H5)2SnCl2 and cis-piatm are studied in D2O under the condition near the physiological one.The results show that the former three complexes mainly and strongly coordinate with the phosphate oxygen of dGMP,while cisplatin mainly coordinates with N(7) of dGMP更多还原

【关键词】 molecular hydrogen complex of osmium； ’H NMR probe； metal anticancer complex； deoxyguanylic acid；
【Key words】 molecular hydrogen complex of osmium； ’H NMR probe； metal anticancer complex； deoxyguanylic acid；

【基金】 Project supported by the National Natural Science Foundation of China;the Natural Science Foundation of Shanxi Province;the Youth Science Foundation of Shanxi Province

【文献出处】 Science in China(Series B) ,中国科学B辑(英文版) , 编辑部邮箱 ,1997年05期

【分类号】O627
【下载频次】29

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[trans-en2Os（η-H2）]2+ as an 1H NMR probe for the coordination of some anticancer metal complexes to deoxyguanotide

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[trans-en₂O_s（η-H₂）]²⁺ as an ¹H NMR probe for the coordination of some anticancer metal complexes to deoxyguanotide