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丙型肝炎病毒在原发性肝癌发生中的作用

Combined effects of hepatitis C virus and other factors on primary hepatic carcinoma

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【作者】 周士新徐道寅孙金兰傅友恒李源泉

【Author】 Zhou Shixin; Xu Daoying; Sun Jinglan; Fu Youhuan; Li Yuanquan (Jiangsu Provincial Sanitary and Anti-epidemic Station, Nanjing 210009)

【机构】 江苏省卫生防疫站!南京210009南京医科大学流行病学教研室南京医科大学三附院

【摘要】 调查江苏省部分地区肝癌患者162人,在同一地区自然人群中选取162人按性别、年龄和职业与肝癌患者进行1:1配对病例对照研究。用ELISA法检测两组人群中的抗-HCV,发现肝癌患者和对照的HCV感染率分别为16.7%和4.32%,两者差异有高度显著性(P<0.01)。根据肝炎病毒的感染途径和其他损害肝功能的因素选取10个变量进行条件Logistic单因素回归分析,结果显示;除静脉输液史和饮酒史外,其他各因素对肝癌均有一定的影响(P<0.05),以HBV感染最为显著;本研究还显示HCV和HBV感染有联合致肝癌作用。

【Abstract】 162 cases of primary hepatic carcinoma were studied in some areas of Jiangsu province. 162 healthy persons were selected in the same place and made 1: 1 matched casecontrol study with PHC patients according to sex, age and occupation. ELISA was used to detect anti-HCV antibody of the two group persons. It was found that HCV infection rates of patients and control were 16. 7% and 4. 32 % respectively. There was significant difference between patients and controls (P<0.01). Ten factors were selected according to the way of hepatitis virus infection and other elements harmful to liver function. Cases of PHC and healthy controls were analyzed by conditional Logistic regress of single-factor. It showed that, apart from the history of intravenous injection and the history of drinking, all other factors are influential to hepatic carcinoma (P<0.05), and it was most noticeable of HBV infection. It also showed that infections of HBV and HCV virus were combined effects on hepatic carcionma.

  • 【文献出处】 疾病控制杂志 ,Chinese Journal of Disease Control and Prevention , 编辑部邮箱 ,1997年01期
  • 【分类号】R735.7
  • 【被引频次】2
  • 【下载频次】25
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