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结核性脑膜炎实验室检查方法的评价

An Evaluation on Laboratory Tests for Tuberculous Meningitis

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【作者】 李秀珍朱长连刘东峰施志欣王小阳

【Author】 Li Xiuzhen et al (The Third Affiliated Hospital of Henan Medical University Zhengzhou 450052)

【机构】 河南医科大学三附院

【摘要】 为了评价结核性脑膜炎(结脑)的实验室检查方法,对20例结脑和28例非结脑患儿的脑脊液分别进行了PCR、抗结核抗体、涂片找结核杆菌及腺苷脱氨酶活性测定。测定结果在结脑组和非结脑组均存在明显差别(P<001),对结脑诊断的敏感性和特异性分别是85%和893%、55%和857%,5%和100%,85%和821%,其中以PCR检查的敏感性和特异性最高,提示PCR是快速诊断结脑的可靠方法。

【Abstract】 For the purpose of evaluating the laboratory tests for tuberculous meningitis, 20 cases tuberculous meningitis and 28 cases non tuberculous meningitis children were studied by polymerase chain reaction,anti-PPD antibody, smear and adenosine deaminase in cerebrospinal fluid. The results showed that all the tests were all different markedly in the two groups. The sensitivity and specificity of the four tests were 85% and 89.3%, 55% and 85.7%, 5% and 100%, 85% and 82.1% reapectively. The polymerase chain reaction were highest in sensitivity and specificity in the four tests. It was suggested that polymerase chain reaction would be the most useful method for the rapidly diagnosis of tuberculous meningitis.

  • 【文献出处】 疾病监测 ,DISEASE SURVEILLANCE , 编辑部邮箱 ,1997年10期
  • 【分类号】R529.3
  • 【下载频次】26
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