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3-取代硫色酮衍生物的合成和抑真菌活性研究

STUDY OF SYNTHESIS AND ANTIFUNGAL ACTIVITY OF THIOCHROMONE DERIVATIVES

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【作者】 于新蕊刘景东李秀敏张国梁方林

【Author】 Yu Xinrui; Liu Jingdong; Li Xiumin (Shijiazhuang Medical College of PLA Shijiazhuang 050081)Zhang Guoliang; Fang Lin (Shenyang University of Pharmacy Science Shenyang 110015)

【机构】 解放军石家庄医学高等专科学校!石家庄050081沈阳药科大学!沈阳110015

【摘要】 报道了疏色酮衍生物的合成路线,合成了七个化合物。抗真菌活性试验结果表明,对供试菌有不同程度的抗菌活性。化合物3-苄基-6-氯硫色满酮的抗真茵活性与克霉唑相当。

【Abstract】 In this paper, the procedure for the synthesis of thiochromone derivatives was reported.7compounds were synthesized. All of them are new compounds which have not been published in literatures. The results of the initial test of antifungal activity in vitro showed that all of them have definite activities against the tested fungi. The activity of 3-benzyl-6-chlor-thiochromanone is equal to clotrimazole’s.

  • 【文献出处】 华西药学杂志 ,WEST CHINA JOURNAL OF PHARMACEUTCAL SCIENCES , 编辑部邮箱 ,1997年04期
  • 【分类号】R914
  • 【被引频次】2
  • 【下载频次】115
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