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高效液相色谱法测定醋酸泼尼松在其复方搽剂中的含量
DETERMINATION OF PREDNISONE ACETATE IN COMPOUND PREDNISONE ACETATE LINIMENT BY HPLC
【摘要】 用RP-HPLC法测定了复方醋酸泼尼松搽剂中醋酸泼尼松的含量。采用Shim-PackCLCODSC18(150mm×6.0-,5μm),以甲醇-水(65:35)为流动相,能使醋酸泼尼松峰得到很好的分离,呈良好的线性关系(r=0.99999),平均回收率为100.31%,RSD为0.73%。
【Abstract】 A method of determination of prednisone acetate in compound prednisone acetate liniment by HPLC was reported. The column is ShimPack, CLC-ODS C18 column(150mm × 6.0mm, 5μm). The mobile phase is water-methanol (35: 65). The results showed that the peak of prednisone acetate was separated, The calibration curves showed a good linearity (r=0. 99999), The average recovery and the coefficient of variation were 100. 31% and 0. 73N, respectively.
- 【文献出处】 华西药学杂志 ,WEST CHINA JOURNAL OF PHARMACEUTCAL SCIENCES , 编辑部邮箱 ,1997年01期
- 【分类号】R284
- 【被引频次】3
- 【下载频次】36