【摘要】 作者通过不同的粘膜途径免疫大鼠 ,观察变形链球菌表面蛋白 P1的免疫防龋效果。将偶联抗原 P1- CTB,P1- PCG经胃肠道 (IG)和鼻腔 (IN)免疫后 ,观察大鼠的患龋情况。实验时间 95 d,结果发现 ,两种途径免疫后 ,实验鼠龋均下降显著。本研究结果提示 P1- CTB,P1- PCG作为一种防龋疫苗具有可行性和实用性更多还原

【Abstract】 To observe the anti caries effects of a small dose of the surface protein antigen P1. The SD rats were immunized with P1 CTB and P1 PCG through IN (intrnasal immunization) and IG (intragastric immunization). The results showed that caries was reduced heavily. There was no obvious difference between IN and IG. P1 CTB and P1 PCG can be used as an antigen to prevent the dental caries, but much further research work still need to do.\;更多还原