【摘要】 合成了标记前体Ｓ－（－）－２－羟基－６－甲氧基－Ｎ－［（１－乙基－２－吡咯烷基）甲基］苯甲酰胺（Ｓ－（－）－ＢＺＭ）。光谱数据与结构相符。以Ｓ－（－）－ＢＺＭ为前体，用１２５Ｉ－ＮａＩ标记，成功地制备了Ｓ－（－）－３－１２５Ｉ－２－羟基－６－甲氧基－Ｎ－［（１－乙基－２－吡咯烷基）甲基］苯甲酰胺（Ｓ－１２５Ｉ－ＩＢＺＭ）。标记率大于８０％，放射化学纯度大于９０％，整个制备过程仅需４５ｍｉｎ，利于药盒化生产。更多还原

【Abstract】 This paper reports syntheses of labelling precursor S (-) 2 hydroxy 6 methoxy N [(1 ethyl 2 pyrrolidinyl)methyl]benzamide( S BZM).The chemical structure is confirmed by spectral data.Using H 2O 2 as oxidizing agent, S BZM is labelled by 125 I NaI at room temperature. S (-) 3 125 I iodo 2 hydroxy 6 methoxy N [(1 ethyl 2 pyrrolidinyl)methyl]benzamide ( S 125 I IBZM) is successfully prepared.Labelling process is simple,the labelling yield is higher than 80%,the radiochemical purity is higher than 90%.更多还原