【摘要】 1993年3月～1995年4月，采用DIP－DFPCF两方案交替治疗食管癌126例，完全缓解49例（38．9％），部分缓解62例（49．2％），稳定12例（9．5％），进展3例（2．4％）。近期有效率88．1％，远期生存率为1年69．8％（88／126），2年34．4％（32／93）。主要毒性为消化道反应和骨髓抑制，无明显肝肾功能损害。更多还原

【Abstract】 From March 1993 to Aprial 1995, 126 evaluable patients with advanced esophageal carcinoma weretreated with the DOP-DFPCF combination regimen. Of them,87 were male and 39 female.The age ranged from 39 to76.All was proved by pathology or cytology.They did not receive any previous treatment andhad a measurable mass. Using DOP-DFPCF alternaive chemotherapy, 2 patients received two cycles oftreatment,4 patients three cycles,5 petients four cycles,8 patients five cycles, 11 patients six cycles, 17patients seven cycles and 79 patients eight cycles. of 126 patients,49 patients (38.9% ) achieved CR,62(49.2% ) PR, 12(9.5% ) S and 3(2.4% ) p.The total response rate was 88. 1 % (111/126) .The 1 and2 year survival rates of the 126 cases were 69. 8% (88/126), 34.4% (32/93), respectively. The maintoxicity observed was nausea, vomiting and bone marrow supression. There was no significant damage tothe function of the liver and the kidneys. In conclusion, DOP-DFPCF regimen can be recommended as achoice of treatment of esophageal cancer.更多还原