【摘要】 以乙醛酸、尿素、苯酚为主要原料，在少量醇的存在下，于强酸性介质中经缩合反应合成了ＤＬ－５－（４－羟基苯基）海因。采用正交设计试验，找出了影响收率的主要因素，确定了最佳反应条件。醇的加入使产物收率提高到７８．７％。更多还原

【Abstract】 Using glyoxalic acid, urea and phenol as starting materials, 5 (4 hydroxyphenyl)hydatoin was prepared by cyclocondensation reaction in the presence of methanol in acidic medium with 78.7% yield. The effects of the reaction conditions on the yield was found by the orthogonal design test method.更多还原