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(R)-N-乙酰四氢噻唑-2-硫酮-4-羧酸与醇的反应

Reaction of (R) Acetylthiazolidine 2 thione 4 carboxylic Acid with Alcohols

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【作者】 李叶芝郎美东申连春黄化民

【Author】 Li,Ye Zhi Lang,Mei Dong Shen,Lian Chun Huang,Hua Min (Department of Chemistry,Jilin University,Changchun,130023)

【机构】 吉林大学化学系

【摘要】 (R)-N-乙酰四氢噻唑-2-硫酮-4-羧酸与醇反应,在SOCl2存在下得到乙酸酯及四氢噻唑-2-硫酮-4-羧酸酯;在碳酸钾存在下得到乙酸酯及四氢噻唑-2-硫酮-4-羧酸;在二环己基碳二亚胺(DCC)存在下得到缩水产物N-乙酰四氢噻唑-2-硫酮-4-羧酸酯。

【Abstract】 The N acetylthiazolidine 2 thione 4 carboxylic acid (2) was obtained through the reaction of acetic anhydride with (R) thiazolidine 2 thione 4 carboxylic acid. Product 2 reacted with benzyl alcohol to produce the corresponding acetic ester and (R) thiazolidine 2 thione 4 carboxylic acid in the presence of K 2CO 3. When the 2 reacted with alcohols in the presence of SOCl 2 the acetic esters and (R) thiazolidine 2 thione 4 carboxylic esters were formed. But the 2 reacted with alcohol in the presence of DCC the (R) N acetylthiazolidine 2 thione 4 carboxylic ester was prepared.

【基金】 国家自然科学基金
  • 【文献出处】 合成化学 ,CHINESE JOURNAL OF SYNTHETIC CHEMISTRY , 编辑部邮箱 ,1997年03期
  • 【分类号】O623.624
  • 【被引频次】2
  • 【下载频次】86
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