【摘要】 实验采用兔肠系膜上动脉闭塞性(SMAO)休克模型,测定了休克前后血中一氧化氮(NO)的含量,动态观察了NO合成抑制剂L-NNA对休克时平均动脉血压(MAP)和肺动脉压(PAP)及对生存时间的影响,并测定了血中丙二醛(MDA)的含量。发现SMAO休克后血中NO含量与休克前相比无明显差异。注入L-NNA后显著增加了休克后PAP,缩短了存活时间,并使血中MDA含量明显增加。提示内源性NO对兔SMAO休克具重要的保护作用。更多还原

【Abstract】 The contents of NO in blood were determined in SMAO shock in rabbits. The effects of the inhibitor of NO, L-NNA on the mean artery pressure (MAP), pulmonary artery pressure(PAP)and survival time were also observed during the shock period. The results showed that the change of NO in blood was not significant before and after shock. PAP increased, survival time is shorttcr and MDA content increased after L-NNA infusion. It is suggested that endogenous NO has the very important protected ef-fect on SMAO shock in rabbits.更多还原