【摘要】 PCR技术的临床应用,对神经系统病毒感染性疾病的早期诊断具有重要意义。我们收集临床诊断神经系统病毒感染性疾病和可能与之相关的疾病的病人的脑脊液25例,非病毒感染性神经系统疾病10例,应用PCR方法,着重检测巨细胞病毒(CMV)、肠道病毒(Enteroviruses)对神经系统的感染,在病毒感染性神经系统疾病中,CMV阳性率为12.5％(2/16),肠道病毒阳性率为52.0％(13/25);在非病毒感染性神经系统疾病中,CMV阳性率为0(0/7),肠道病毒阳性率为0(0/10)。以上提示肠道病毒是引起病毒性神经系统疾病的重要因素,同时也表明:PCR技术作为一种简单、快速、敏感的检测方法,不但对神经系统病毒感染性疾病的早期诊断有意义,对于疾病的预后和疗效观察也有重要价值。更多还原

【Abstract】 We checked the CSF of 25 patients who were diag-nosed with virusinfected nervous system diseases or other related ailments, by polymcrasc chain reation (PCR). Thirteen of the twenty-five patients (52%) who were ex-amined for Enteroviruses and two of sixteen patients (12. 5%) who were examined for CMV showed positive re-sults. All the ten patients with non-virus infected nervous system diseases revealed negative results. These results suggested that Enterovirus is among the important factors which may cause various infective diseases of nervous sys-tem. Especially, human virus encephalitis was involved with Enterovirus. PCR may be taken as a simple, fast and sensitive method, not only leave great significient in diag-nosing infective diseases of nervous system at the early stage but predict prognosis and observation of curative ef-fect.更多还原