【摘要】 1992年4月～1994年12月,对广西南宁、桂林等6个市县城乡地区自然人群2086人进行戊型肝炎感染流行状况调查研究。用ELISA法检测血清抗 -HEV -IgG。结果表明自然人群中有较高的HEV感染,抗 -HEV标化阳性率为20.2 %。各地区的HEV感染率有较大的差别,从8.6 %至47.0%,以桂西北山区壮族聚集的凌云县最高(47.0 %) ,南宁市最低(8.6 %)。城市人群HEV感染率(16.0 %)低于农村(21.8 %)(P<0.01)。HEV感染率随年龄增长而上升,生命早期即有高度的HEV感染,1～4岁为7.2 %,5～9岁开始上升(9.0 %),10岁以后感染率成倍增加(14.8 %～29.7 %) ,有两个小峰分别在30～39岁(29.3 %)和50岁以上(33.3 %)。HEV感染率高峰年龄较国内外提前10年 ,男女性总抗 -HEV阳性率无明显差别(分别为18.8 %和21.2 %),但10～39岁女性抗HEV阳性率(26.2 %)高于男性(19.8 %),P<0.01,说明人群对HEV普遍易感。结果表明广西为我国戊型肝炎高感染区 ,对导致广西地区高HEV流行率的有关流行因素进行了讨论。更多还原

【Abstract】 In June,1992-Oct.1994, a hepatitis E virus(HEV) sero-epidemiological study was carried out in Guilin, Nanning, Hepu, Binyang, Locheng and Linyun cities and counties of Guangxi, China. A total of 2086 serum samples were assayed for anti-HEV by ELISA (HEV ELISA, Diagnostic Biotechnology(PTE) Ltd., Singapore). The results showed that: HEV infection was higher in general population; the seroprevalence of anti-HEV was 20.2% (ranged 8.6～47.0%); positivity for anti-HEV was higher in rural population (21.8%) than in urban population (16.0%), P<0.01. In the Region, the HEV infection occurs mainly in early childhood; the rates increased steadily with age, it was 7.2% in persons<5 years old, at ages 5 to 9, the rate increases to 9.0%, reaching two peaks of 29.3% and 33.2% in ages 30～39 and more than 50. The peak rates of anti-HEV were earlier 10 years in Guangxi than those in other areas. The prevalence of anti-HEV was no difference between males and females. This survey shows that there is a high prevalence of HEV infection in Guangxi even though no outbreaks of non-A, non-B hepatitis have been reported, and the area distribution of hepatitis E is also wide. The epidemiological factors of HEV infection in the Region are under investigation.更多还原