【摘要】 报告了６只新西兰白兔灌服地高辛前后对稳态时氨茶碱药代动力学的影响。实验分３期：Ⅰ期为第１～４天单独灌服氨茶碱至稳态；Ⅱ期为第５～１１天单用地高辛，第１２～１５天合用地高辛与氨茶碱；Ⅲ期于第１６～２２天同停用氨茶碱与地高辛，第２３～２６天单用氨茶碱。各期测得氨茶碱药代动力学参数，经统计学处理，与Ⅰ期比较Ⅱ、Ⅲ期的ＡＵＣ、ＣＬ／Ｆｓ有显著性差异（Ｐ＜０．０５），Ⅱ期与Ⅲ期比较则无显著性差异，而Ｔα１／２、Ｔβ１／２、Ｔｍａｘ、Ｃｍａｘ各期之间差异均无显著性。更多还原

【Abstract】 The effect of oral digoxin on aminophylline pharmacokinetics was evaluated in 6 New Zealand rabbits . The experiment was divided into 3 stages:(1)the subjects only received a four day course of oral aminophylline until steady state;(2)from the day 5 to 11 digoxin was administrated (0.25mg daily),then,aminophylline and digoxin were coadministrated since the day 12;(3)from the day 16 to 22,aminophylline and digoxin were stopped ,next, aminophylline was given to a steady course during a four day course.After the last dose of aminophylline at the end of each study stage,the theophylline level in plasma was analyzed with HPLC. Each subjectd acted as its own control.Compared to stage Ⅰ,area under the curve(AUC) and steady state clearance(CL/Fs)had significantly change at stage Ⅱ and stage Ⅲ (P<0.05),and there was no significant difference for other parameters.更多还原