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以ALS为靶标的新型除草剂的分子设计、合成及生物活性研究(Ⅲ)──5,7-二甲基-N-(取代苯基)-1,2,4-三唑并[1,5-a]嘧啶-2-磺酰胺的晶体及分子结构
Design, Syntheses and Biological Activity of Novel Herbicides Targeted ALS(Ⅲ)─Crystal and Molecular Structure of 5,7-Dimethyl-N-(substitutedphenyl)-1, 2, 4-triazolo [1,5-a] pyrimidine-2-sulfonamide
【摘要】 在合成标题化合物的基础上,测定了其晶体结构.由于苯环邻位取代基的差异,导致了两者在空间构象上的极大差异,从而引起它们生物活性的绝然不同.与磺酰脲类除草剂的晶体结构进行比较后发现,这两类除草剂的空间构象与生物活性间的关系是完全一致的,从而进一步说明了它们与ALS可能具有相同的结合位点.
【Abstract】 The title compound was syntheslzed and analysed by X-ray diffraction. The difference of ortho-substituents resulted in the great difference in conformation and their herbicidal activity. Compared with the crystal structures of herbicidal sulfonurea, the same structure-activity relationship as that of sulfonurea can be found in sulfonamides, which indicatedthat this two kinds of herbicides might have the same binding site on ALS.
【关键词】 磺酰胺;
X射线衍射;
晶体结构;
构效关系;
【Key words】 Sulfonylamide; X-ray diffraction; Crystal structure; Structure-activity relationship;
【Key words】 Sulfonylamide; X-ray diffraction; Crystal structure; Structure-activity relationship;
【基金】 国家自然科学基金
- 【文献出处】 高等学校化学学报 ,CHEMICAL RESEARCH IN CHINESE UNIVERSITIES , 编辑部邮箱 ,1997年12期
- 【分类号】O625
- 【被引频次】21
- 【下载频次】176