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胃癌患者胃粘膜上皮细胞凋亡的观察

APOPTOSIS IN EPITHELIAL CELLS OF STOMACH MUCOSA IN GASTRIC CARCINOMA PATIENTS

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【作者】 杨绮红欧晓军蔡亚娜

【Author】 Yang Yihong Ou Xiaojun Cai Yana (Guangzhou Red Gross Hospital, Guangzhou 510220) (Guangzhou Teachers’ College, Guangzhou 510400)

【机构】 广州市红十字会医院广州师范学院生物系 广州510220广州510220510400

【摘要】 本文对31例胃癌、胃癌并转移及胃炎患者胃粘膜上皮细胞的凋亡进行了观察和比较.通过纤维胃镜取材,石蜡包埋,H.E染色,油镜镜检.结果是未转移胃癌患者细胞凋亡出现频率的均值最低(7.1‰),已转移的胃癌患者最高(28.8 ‰),两者间有极显著性差异(P<0.001),而胃炎患者的细胞调亡频率介于前两者之间(18.3‰).结果提示:未转移因癌患者胃粘膜上皮细胞凋亡的频率低下,与近代肿瘤形成的观点相符,即恶性肿瘤发生原因之一是由于应该死亡的细胞过少死亡的结果.

【Abstract】 This paper observed and compared the apoptosis in epithelial cells of stomach mucosa from 31 patients of gastric cancers, metastastic gastric cancer, and gastritis. The cells were taken by gatrofiberscopy, embeded in parafin, stained with H. E and examed under oil immersion. The mean frequency of apoptosis of gastric cancer patients was the lowest (7.1‰), metastatic stomach cancer patients showing the highest frequency (28. 8‰). The difference of these two groups was significant (P<0.001).The frequency of gastritis parients was the above two groups (18.3‰). The apoptosis frequency of the non-metastic gastric cancer patients was the lowest among the three groups. The result was in accordance with the update theory of cancer formation: one of the causes of cancer is that the cells that should die keep alive.

【关键词】 细胞凋亡胃癌
【Key words】 apoptosisgastric carcinoma
  • 【分类号】R735.2
  • 【下载频次】28
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