【摘要】 改进血清中异烟肼的提取方法，建立了生物组织检材内异胭肼的提取和薄层色谱扫描检测方法，线性范围为2～32ug／ml或g，检出限为0．5ug／ml或g。l例异烟擀中毒死亡者体内异烟肼分布：肾31．6mg／100g、肝26．6mg／100g、脾22．1mg／100g、心21．3mg／100g、胃16．6mg／100g、脑15．5mg／100m、肺12．6mm／100g、小脑11．7mm／100g和10.5mm／100ml。更多还原

【Abstract】 The determination of isoniazid(INH) in biological tissue specimen by TLC is reported. INH in bi-ological tissue was derivatized with salicyladehyde and benzaldehyde,and was extracted with ethylac-etate or diethyl ether - dichloromethane (2: 3 ). The standard curves were linear in the range of 2～32ug/ml or g. The limit of detection of the INH in specimen was 0. 5ug/ml or g. The concentrationsof INH in internal organs of a young woman died of INH overdose were as follows: kidney 31. 6mg/100g, liver 26. 6mg/100g, spleen 22. 1mg/100g, heart 21. 3mg/100g, stomach 16. 6mg/100g, brain15. 5mg/100g , cerebellum 11. 2mg/100g and blood 10. 5mg/100ml.更多还原