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中国人血清脱氧核糖核酸酶I(DNase I)的遗传多态性研究
GENETIC POLYMORPHISM OF HUMAN SERUM DNase I IN CHINESE POPULATIONS
【摘要】 应用薄层PAGIF(T=5%,C=3%)结合特异酶底物染色技术,调查了中国随机人群DNaseI遗传多态性的分布,检出在中国人群中两种常见的等位基因,即DNaseI*1和DNasel*2,其基因频率DNaseI*1为0.53,DNaseI*2为0.47。家系分析表明:子代个体谱带分别来自父亲和母亲,谱带在亲代和子代之间的传递符合孟德尔遗传规律。按Hardy-Weinberg法则进行吻合度检验,观察值与期望值一致。人血清DNaseI等电点经测定为4.0。
【Abstract】 The results of DNase I phenotyping using PAGIF followed by zymograln detecting method ispresent and two commom alleles DNase I * 1 and DNase I * 2 were detected- The gene frequenciesare 0. 53 and .0. 47 respectively. The results of family analysis obey The Mendel Laws. The observednumbers of the phenotypes are in good agreement with the Hardy-weinberg equelibrium. The pI ispH4. 0.
- 【文献出处】 中国法医学杂志 ,CHINESE JOURNAL OF FORENSIC MEDICINE , 编辑部邮箱 ,1997年03期
- 【分类号】R394.3
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