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骨碱性磷酸酶试剂盒对儿童大骨节病早期诊断的研究

EARLYDIAGNOSTIC STUDY OF CHILDREN’S KASHIH-BECK DISEASE WITH BONE ALKALINE PHOSPHATASE

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【作者】 李金卯; 杨世明; 赵君; 温春生; 丁生荣; 王晨明; 王祖郧; 文海; 毛续山; ■德扎西; 孙莉;

【Author】 Li Jinmao ,et alHebei Provincial Institute for Endemic Diseases Control

【机构】 河北省地方病防治所; 青海省地方病防治研究所; 青海省兴海县防疫站; 河北省第二附属医院;

【摘要】 1996年7~10月,对大骨节病区136例、非病区46例,7~12岁儿童进行了右手X线检查,同时测定了骨碱性磷酸酶(BALP)。结果:X线查出大骨节病46.32%,BALP查出56.62%,X线诊断与BALP诊断符合率为92.06%。在病区X线检查正常者中,BALP检出阳性率为26.03%。BALP化验指标的诊断试验灵敏度92.06,特异度95.65,误诊率4.35,漏诊率7.94,准确度93.58。说明BALP测定方法对大骨节病早期诊断有较高的临床应用价值。

【Abstract】 From July to October in 1996,we took the right hand X-ray pictures on 182 children who were from seven to twelve years old , with 136 cases being in the Kashin-Beck disease areas and the others being not. The proportion of patients was 46. 32 percent. We also tested their BALP. The proportion of patients was 56. 62 percent. The proportion of accordance in the diagnosis was ercent. When we used BALP to test the cases in the Kashin-Beck disease areas whose X-res were normal,we got the positive rate 26. 03 percent. The BALP laboratory test indexes ,sensitivity was 92. 06 percent ,specificity was 95. 65 percent. Mistake diagnose rate was 4. 35 percent ,omission diagnose rate was 7. 94 percent ,accuracy was 93. 58 percent. So the following conclusion was drawn: BALP was of great clinic value in early diagnosis possible of Kashin-Beck disease.

  • 【文献出处】 中国地方病防治杂志 ,Chinese Journal of Control of Endemic Disease , 编辑部邮箱 ,1997年03期
  • 【分类号】R726.8
  • 【下载频次】57
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