【摘要】 为临床治疗急性呼吸窘迫综合征(ARDS)寻找新的有效药物,选用肝素对ARDS动物模型进行防治,观察疗效。结果发现,肝素可改善ARDS动物的血氧分压(PaO2)、动脉血氧饱和度(SaO2)、动脉和肺病理变化,但有加重肺出血的现象。实验表明,抗凝治疗可改善ARDS动物肺循环状态和血气变化,减轻肺损伤程度。但肝素由于其易引起肺出血而不宜使用。今后有必要用其它抗凝药物来进行进一步的研究。更多还原

【Abstract】 To find out new drugs wh:ch have good therapeutic effect on acute respiratory sistress syndrome (ARDS) ,heparin was selected to treat the ARDS in rat model. The results showed that heparin could improve the PaO2, SaO2and the pathological changes in lung of ARDS rats. But it might induce lung hemorrhage. The results suggested that antieoagula-tion treatment could improve pulmonary bypercoagulation state’ and blood gases of ARDS, attenuate the lung injury. But heparin is not good for ARDS. It is necessary to use other an-ticoagulable drugs to do further study.更多还原