【摘要】 本实验旨在探讨不同量的一氧化氮对３０％酒精致大鼠胃粘膜损伤的作用和一氧化氮对肥大细胞的可能调节作用。结果揭示内源性一氧化氮对胃粘膜有保护作用，而较大剂量的外源性一氧化氮可加重胃粘膜损伤，且呈剂量依赖性，一氧化氮对胃粘膜完整性的影响可能与一氧化氮的量及机体的病理生理状态有关。有关一氧化氮与肥大细胞之间的关系本实验尚不能得出结论。更多还原

【Abstract】 This study was designed to explore effects of nitric oxide (NO)in 30% ethanol-induced gastric mucosal injury in rats and to determine if NO could regulate the functions of mast cells (MC)and if MC could be implicated in NO injured gastric mucosaThe result suggests that endogenous NO can exert a protective effect on gastric mucosa,but larger amounts of exogenous NO can exacerbate gastric mucosal damage in a dose-dependent wayParadoxical effects of NO on gastric mucosal integrity can have something to do with the amounts of NO and the pathophysiological conditions The present results may not draw a conclusion about the relationship between MC and NO The potential mechanism through which NO can protect or damage the gastric mucosa is needed to investigate.更多还原