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病毒性肝炎病人外周血T淋巴细胞亚群检测意义的再认识
SIGNIFICANCE OF DETECTING PERIPHERAL BLOOD T LYMPHOCYTE SUBGROUPS IN PATIENTS WITH VIRAL HEPATITIS
【摘要】 对150例病毒性肝炎病人采用免疲荧光抗体法进行了外周血 T 淋巴细胞亚群的检测,以30名健康人为对照,并探讨了该亚群与 ALT、HBV—M的关系。与对照组相比,AH、CPH、CAH、LC 组,除 LC 组 CD8+,AH 组 CD4+/CD8+外,CD3+、CD4+、CD8+、CD4+/CD8+均明显减少(P<0.01),但各临床分型闻无显著差异(P>0.05);ALT 50u 以下及以上组,除50u 以下组CD8+,51u 以上组 CD4+/CD8+外,CD3+、CD4+、CD8+、CD4+/CD8+均明显减少(P<0.01);CAH 的HBeAg(+)和(或)抗 HBcIgM(+)组、抗 HBs(+)和(或)抗 HBe(+)组只有 CD3+、CD4+明显减少(P<0.01),HBeAg(+)和(或)抗 HBcIgM(+)组 CD4+/CD8+减少(P<0.05)。
【Abstract】 The peripheral blood T lymphocyte subgroups were detected by immunofluorescent antibody technique in 150 cases of viral hepatitis and in 30 heathy persons.The relationships between the T lymphocyte subgroups and ALT or HBV-M were discussed.As compared with the healthy persons,the levels of CD3+,CD4+,CD8+ and CD4+/CD8+ in the AH,CPH,CAH and LC group were decreased notably(P<0.01),but there were no significant difference among the clinical types(P<0.05);the levels of CD3+,CD4+ CD8+ and CD4+/CD8+ in ALT activity more or less than 50u/L groups were decreased obviously(P<0.01);the levels of CD3+ andCD4+ were decreased notably in HBeAg(+)and /or anti-HBclgM(+)group and in anti-HBs(+)and/or anti-HBe(+) group of CAH,the levels of CD4+/CD<sup>8+ were decreased in HBeAg(+)and/or anti- HBclgM(+)group(P<0.05).
【Key words】 viral hepatitis; T lymphocyte subgroup; ALT; HBV-M; immunofluorescent antibody technique;
- 【文献出处】 承德医学院学报 ,Journal of Chengdu Medical College , 编辑部邮箱 ,1997年02期
- 【分类号】R512.6
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