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病毒性肝炎病人外周血T淋巴细胞亚群检测意义的再认识

SIGNIFICANCE OF DETECTING PERIPHERAL BLOOD T LYMPHOCYTE SUBGROUPS IN PATIENTS WITH VIRAL HEPATITIS

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【作者】 钟玉芳刘跃敏刘金霞张建华尹小春李瑞民邓淑华宋鸿儒于兴海

【Author】 Zhong Yufang Department of Infective Disease,Affiliated Hospital

【机构】 承德医学院附属医院三内科承德医学院附属医院三内科承德医学院微生物教研室承德市中心血站

【摘要】 对150例病毒性肝炎病人采用免疲荧光抗体法进行了外周血 T 淋巴细胞亚群的检测,以30名健康人为对照,并探讨了该亚群与 ALT、HBV—M的关系。与对照组相比,AH、CPH、CAH、LC 组,除 LC 组 CD8+,AH 组 CD4+/CD8+外,CD3+、CD4+、CD8+、CD4+/CD8+均明显减少(P<0.01),但各临床分型闻无显著差异(P>0.05);ALT 50u 以下及以上组,除50u 以下组CD8+,51u 以上组 CD4+/CD8+外,CD3+、CD4+、CD8+、CD4+/CD8+均明显减少(P<0.01);CAH 的HBeAg(+)和(或)抗 HBcIgM(+)组、抗 HBs(+)和(或)抗 HBe(+)组只有 CD3+、CD4+明显减少(P<0.01),HBeAg(+)和(或)抗 HBcIgM(+)组 CD4+/CD8+减少(P<0.05)。

【Abstract】 The peripheral blood T lymphocyte subgroups were detected by immunofluorescent antibody technique in 150 cases of viral hepatitis and in 30 heathy persons.The relationships between the T lymphocyte subgroups and ALT or HBV-M were discussed.As compared with the healthy persons,the levels of CD3+,CD4+,CD8+ and CD4+/CD8+ in the AH,CPH,CAH and LC group were decreased notably(P<0.01),but there were no significant difference among the clinical types(P<0.05);the levels of CD3+,CD4+ CD8+ and CD4+/CD8+ in ALT activity more or less than 50u/L groups were decreased obviously(P<0.01);the levels of CD3+ andCD4+ were decreased notably in HBeAg(+)and /or anti-HBclgM(+)group and in anti-HBs(+)and/or anti-HBe(+) group of CAH,the levels of CD4+/CD<sup>8+ were decreased in HBeAg(+)and/or anti- HBclgM(+)group(P<0.05).

  • 【文献出处】 承德医学院学报 ,Journal of Chengdu Medical College , 编辑部邮箱 ,1997年02期
  • 【分类号】R512.6
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