【摘要】 目的：了解抗中性粒细胞胞浆抗体（ANCA）在国内溃疡性结肠炎（UC）病人中的阳性率、对UC的诊断意义及其与病理改变之间的关系。方法：间接免疫荧光法检测ANCA；常规病理学观察肠粘膜炎症程度及肠粘膜血管炎。结果：40例UC病人中13例（32．5％）ANCA阳性，而15例肠易激综合征，4例克隆病，15例其它原因引起腹泻的病人，以及49例健康对照全部ANCA阴性。ANCA对UC的敏感性和特异性分别为32．5％和100％。病理学检查发现，ANCA阳性者肠粘膜炎症程度较重，粘膜血管炎发生率较高。结论：ANCA对鉴别UC与其他腹泻性疾病有意义；ANCA可能通过介导肠粘膜血管炎参与UC的发病。更多还原

【Abstract】 Objective: To evaluate the diagnotic value and pathogenic role of antineutrophil cytoplasmic antiboby(ANCA) in ulcerative colitis(UC). Methods: ANCA was detected by indirect immunofluoresence.Pathologic changes of colonic mucosal biopsies were studied. Results: 13/40 (32. 5% ) UC patients were ANCA positive, including 12 pANCA and 1 cANCA; while 34 disease control and 49 healthy control subjects were all ANCA negative. The sensitivity and specificity of ANCA fOr UC was 32. 5% and 100%,respectively Pathologic study showed that ANCA positive patients had a higher prevalence of mucosal vasculitis (91. 7% vs 45. 0%, P < 0. 05 ) and higher degree (Ⅲ ~ Ⅴ grades) of mucosal inflammation (77. 8% vs 33. 3 %, P < 0. 05) than ANCA negative patients. Conclusions: ANCA is a specific clinica test for differential diagnosis of UC in diarrheic patients. ANCA may participate in the pathogenesis of UC by inducing mucosal vasculitis.更多还原