【摘要】 目的：研究脂蛋白（a）[Lp（a）]与老年动脉硬化性疾病的关系，并探讨LP（a）是否通过抑制纤溶系统起作用。方法：对157例老年患者及健康志愿者进行了Lp（a）及部分凝血和纤溶因子的测定，按年龄及疾病情况分为5组。结果：Lp（a）水平在冠心病及脑血检组明显升高，分别为（364±378）mg／L及（34±180）mg／L，明显高于高血压组和健康对照组，各组部分凝血及纤溶因子水平差别无显著性。Lp（a）水平与性别、年龄、体重指数、吸烟与否、血脂指标、凝血及纤溶因子间无相关性。结论：Lp（a）升高是冠心病及脑血栓的一个独立的危险因素，推测Lp（a）并非主要通过抑制纤溶系统起作用，或者对纤溶的作用具有某些时相性。更多还原

【Abstract】 Objective: To study the relations between lipoprotein(a) [Lp (a)]and the diseases of senile arteriosclerosis and investigate whether Lp (a)acts by inhibiting fibrinolytic system. Methods: Lp (a) andvarious hemostatic factors were determinde in 157 senile patients(divided into 5 groups)and healthy volunteers. Results: Lp (a)is (364±378) mg/L and (349±180) mg/L in coronary heart disease group andcerebral thrombosis group respectivily,which are significantly higher than these in hypertension groupand healthy control group. The difference of hernostatic factors between the various groupsis not significunt. No correlation was found between Lp (a) level and sex,age,body mass index, smoking, blood-lipid,hemostatic factors. Conclusion: Elevated Lp (a)is an independent dangerous factor for coronary heart disease and cerebral thrombosis,and it does not act by inhibiting fibrinolytic system,or its action is phasic.更多还原