【摘要】 目的：观察实验性高脂血症对肾病鼠的肾毒性作用。方法：阿霉素肾病鼠随机分为两组，分别饲以高脂饲料和普通饲料，测定其血脂，肾功能、尿蛋白和肾皮质SOD，并进行肾组织学观察。结果：肾病高脂饮食组与肾病对照组比较，2周后血胆固醇、甘油三酯明显升高，8周后肌酐清除率和肾皮质SOD水平明显下降。结论：过量的脂质可加速肾病时肾损伤且与自由基代谢失衡有关。更多还原

【Abstract】 Objective:The effect of experimental hyperlipidemia on nephrotoxicity of nephrotic rats wasstudied. Methods: Adriamycin-induced nephrotic rats were randomized into 2 groups, feeding with hyperlipidic diet or general diet. The plasma lipids, renal function, protein in urine and SOD in renal cortex were measured. The renal morphological change was observed. Results: In hyperlipidic diet group,the plasma cholesterol and triglyceride elevated significantly after 2 weeks (p<0. 05), the creatinineclearance rate and the level of SOD in renal cortex were decreased significantly after 8 weeks (p<0. 05).Conclusion: Overload of lipid can induce the progression of renal injury in nephrotic syndrome which isalso related with the abnormal metabolism of oxygenic free-radical.更多还原