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HCV感染的献血者血清中病毒量的检测及分析

Quantitative Detection and Analysis of HCV RNA in Sera of HCV infected Blood Donors

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【作者】 史宣玲季阳任勤惠朱志议

【Author】 Shi Xuanling,et al (Institute of Blood Transfusion,Chinese Academy of Medical Sciences and Peking Union Medical College)

【机构】 中国医学科学院中国协和医科大学输血研究所

【摘要】 选取16名经血清HCV-RNAPCR测定为阳性的HCV感染的献血者进行血清病毒含量的检测。这些献血者发生HCV感染的期限约2年,其HCVRNA含量在103.5~105.5拷贝/ml,随着血清中HCVRNA含量的增加,ALT水平异常者的数量似亦相应增加。由于这些HCV感染的献血者均未经过任何与肝炎有关的治疗,所以继续追踪观察的结果将有助于评价血清中病毒含量与HCV致病及预后的关系。

【Abstract】 The HCV RNA content in sera has been detected in sixteen recruited blood donors whose sera tested for HCV RNA by PCR was positive.The time of HCV infection in these blood donors was about two years.The HCV RNA content in their sera amounted to 10 3.5 ~10 5.5 copies/ml.So,the number of blood donors with abnormal ALT level seemed to be increased as HCV RNA content in their sera was risen.As these HCV infected blood donors did not receive any treatment concerned with hapatitis,the result of follow up observation will be useful for evaluation of relationship between HCV RNA content in their sera and pathogenesis and prognosis of HCV.

【关键词】 HCV感染献血者HCV病毒量
【Key words】 HCV infectionblood donorsHCV RNA content
  • 【文献出处】 中国输血杂志 ,CHINESE JOURNAL OF BLOOD TRANSFUSION , 编辑部邮箱 ,1997年03期
  • 【分类号】R446
  • 【被引频次】11
  • 【下载频次】43
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