【摘要】 ①目的探讨喉癌病人血清肿瘤坏死因子（ＴＮＦ）水平的改变及其临床意义。②方法采用ＥＬＩＳＡ法测定３７例喉鳞状细胞癌病人、２５例喉良性疾病病人和４０例正常人血清ＴＮＦ水平。③结果喉癌病人血清ＴＮＦ水平较良性疾病组和正常对照组增高（ｔ′＝５．８２，５．６７，Ｐ均＜０．０１）；以大于正常对照组血清ＴＮＦ的ｘ±２ｓ为阳性，喉癌组阳性率为７５．７％，良性疾病组阳性率为８．０％，两组比较差异有极显著性（χ２＝２４．７２，Ｐ＜０．０１）；喉癌病人血清ＴＮＦ水平与临床分期无关（ｔ＝０．１６，Ｐ＞０．０５）。④结论喉癌病人血清ＴＮＦ水平升高，检测血清ＴＮＦ水平有助于喉癌的诊断。更多还原

【Abstract】 Objective To study the changes and the clinical significance of serum tumor necrosis factor(TNF) in patients with laryngocarcinoma. Methods The serum TNF were measured with ELISA method in 37 patients with squamous cell carcinoma of larynx, 25 patients with benign lesion of larynx and 40 normal controls. Results The serum TNF levels were significantly higher in the patients with laryngocarcinoma than in the patients with benign lesion and the normal controls( t′=5.82,5.76,P <0 01). Taken the normal controls TNF ±2s as the mean value, there were 75.7% laryngocarcinoma and 8.0% benign lesion above this limit which were considered positive and the positivity of the two groups were significantly different( χ 2=24.7,P <0 01). The serum TNF levels in the patients with laryngocarcinoma had no correlation with the clinical stages. Conclusions The serum TNF level in patients with laryngocarcinoma were elevated. The determination of serum TNF may be valuable in the diagnosis of laryngocarcinoma.更多还原