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柑皮油对二乙基亚硝胺诱发大鼠肝癌前病变的抑制
Inhibitory effect of citrus peel oil on hepatocarcinogenesis of diethylni trosamine in rats
【摘要】 用二乙基亚硝胺(DEN)致大鼠肝癌前病变实验模型,研究从鲜柑皮提取的挥发性柑皮油对致癌作用的影响。于大鼠接受 DEN 前10天起,饲以含5%柑皮油饲料。经两次重复实验,结果均显示:肝癌前病变 Gam-ma-谷氨酰转肽酶阳性肝细胞增生灶(GGT 灶)的发生数(个/cm~2),用柑皮油组明显少于单给 DEN 的对照组(P<0.05~0.01),对 GGT 灶数的抑制率可达44.0%;灶面积(mm~2/cm~2)也小于对照组(P<0.05),对灶增长的抑制率可达55.73%。表明柑皮油有抑制 DEN 致大鼠肝癌前病变发生发展的作用。
【Abstract】 5% citrus peel oil (CPO) containing diet was fed to the rats 10 days prior one dose of diethylnitrosamine (DEN,i.p.)to 3-7 days after DEN exposure.The occurrence of precancerous le- sions of the liver induced by DEN was inhibited.The liver cell precancerous hyperplastic foci positive for gamma-glutalmyltranspeptidase (GGT foci) in the rats treated with CPO was much less and smaller than those exposed to DEN alone (P<0.05).The inhibition rate in the number of GGT foci (No./ cm~2) may reach 44.0 % and in the area of GGT foci (mm~2/cm~2) may reach 55.73 %.These results sug- gest that CPO possesses the inhibitory effect on DEN hepatocarcinogenesis.
【Key words】 Diethylnitrosamine; Citrus peel oil; Hepatocarcinogenesis Precancerous lesion; Chemoprevention;
- 【文献出处】 癌症 ,Chinese Journal of Cancer , 编辑部邮箱 ,1997年01期
- 【分类号】R735.7
- 【被引频次】9
- 【下载频次】46