【摘要】 对血吸虫病肝纤维化家兔杀虫治疗后,用肝疏胶囊二档剂量进行抗肝纤维化的研究,并设正常对照组、病理对照组、阳性药物组(秋水仙碱)。计算机图像处理系统对各组进行显微肝组织胶原纤维面积百分比测算结果,各药物治疗组面积百分比较病理对照组、正常对照组显著降低(P<0.01,P<0.05),尤以肝疏胶囊大剂量组为优。提示血吸虫病肝纤维化杀虫治疗尚不能代替药物抗肝纤维化;肝疏胶囊和秋水仙碱均可阻止和逆转肝纤维组织增生,为肝疏胶囊的开发研究提供了客观依据。更多还原

【Abstract】 The effect of high and low dosage Ganshu capsula(GSC)on liver fibrosis of rabbit after pesticide treatment for Schis- tosomiasis was observed.The authors designed three groups:normal control,pathological control and positive medicament group(group of colchicine).The area(percentage)of micro-liver collagenous fibers were calculated by using image pro- cessing system.Results:the area of all the medicament groups were remarkably lower than that of control group(P<0. 01 or P<0.05).Especially high dosage group of GSC was very good.The area of pathological control group(35.44± 11.34)was larger than that of normal control group(27.72±16.36).The results indicated that liver fibrosis pesticide treatment for schistosomiasis could not substitute for medicament treatment respectively.GSC and colchicine could reduce and reverse hyperplasia of liver fibrous tissue.The results provided objective evidence for explore research.更多还原