【摘要】 本研究观察了沙参麦冬汤对胃-空肠吻合及长期饮用氨水所致大鼠慢性胃粘膜损伤的保护作用。大鼠胃肠吻合周后,胃体部粘膜充血或瘀血,水肿明显,胃内 pH值及胆酸含量上升,镜下,粘膜内及粘膜下炎症明显,沙参麦冬汤能显著对抗上述胃粘膜病理变化,并能降低胃内 pH 值,但对胆酸含量无明显影响。大鼠持续饮用氨水(0.02%)12周,胃粘膜表面出现弥漫性不规则的线状红肿,附有白苔。镜下,可见胃体部腺体变短,胃粘膜PAS 染色阳性层明显变薄。沙参麦冬汤对上述胃粘膜病理改变有明显保护作用。更多还原

【Abstract】 The protective effects of Shashen Maidong decoction(SSMDD)on the rats with chronic gastric mucosal lesions in- duced by gastrojejunostomy,or by ammonia water given orally in a long period were observed.It was demonstraded that 12 weeks after gastrojejunostomy,intragastric PH value and bile acid concentrations were significantly elevated.Micro- scopic study of the lesions in the reflux group elevals marked engorgement of microvessels and hemorrhage or round lesions with marginal swelling.Administering SSMDD could prevent the histopathologic changes of the gastric mucosa as well as reduce the PH value,but it made no differences in the bile acid concentration in the gastric juice.After feeding the rats with 0.02% ammonia water for 12 months microscopically the gastric mucosa showed diffuse irregular linear areas of red- ness and swelling covered with white exudates,and microscopically the significant atrophic change of corpus mucosal glan- dular structure were seen.The PAS positive staining layer of the gastric mucosa in the rats fed with ammonia water be- came significantly thinner than that of the control rats;SSMDD could protect the rats against the above histopatbologic changes of the gastric mucosa.更多还原