【摘要】 用放射免疫分析法检测血浆血栓素 B₂（TXB₂）和6-酮-前列腺素 F_1α(6-keto-PGF_1α)水平。结果表明:在弥漫性血管内凝血（DIC）模型中,TXB₂、6-keto-PGF_1α及 TXB₂/6-keto-PGF_1α比值显著上升（P<0.01,P<0.01,P<0.001）,而布洛芬、雷公藤则能明显地降低 TXB₂/6-keto-PGF_1α比值（P<0.01,P<0.05）,减轻内毒素 DIC 所致的多脏器损伤。提示雷公藤调节 TXB₂/6-keto-PGF_1α的平衡可能是其抗内毒素性 DIC 损伤的机制之一。更多还原

【Abstract】 The SD rats were fed with Tripterygium（20mg/kg）or Ibuprofen（30mg/kg）everyday for one week Experimental models of endotoxin-induced disseminated intravascular coagulation（DIC）were made according to the method described by F Kunz,et al.The plasma levels of TXB2 and 6-keto-PGF_1αwere measured with radioimmunoassay.It was found th at both the plasma levels of TXB₂ and 6-keto-PGF_1αand the ratio between them had increased significantly in the model group.After treated with Tripterygium or Ibuprofen,the experimental animals’ plasma levels of TXP,2 and 6-keto-PGF_1α and the ratio between them had decreased markedly compared with model group.It was suggested that the treatment of Ibuprofen or Tripterygium could reduce the damage produced by DIC on experimental animals.Ohe of the mechanisms of the therapeutic effect of Triperygium on DIC might be attributed to the regulation of the ratio balance of TXB₂ to 6-keto- PGF_1αin plasma.更多还原