【摘要】 对全身亚致死量⁶⁰Co 照射后的小鼠立即腹腔注射磷酸川芎嗪注射液250mg/kg,每天2次,连续7天,观察尺骨骨髓切片。第5天,川芎嗪组骨髓微血管数较对照组明显增多,第7天,对照组已降到正常值,而川芎嗪组仍持续增多,而且微血管面积明显扩张。应用川芎嗪7天内尺骨骨髓造血组织容量百分率与对照组比较,无明显差异;但照射后第7天,川芎嗪组外周血中性粒细胞比率有所上升。上述结果提示,在急性放射损伤后早期应用川芎嗪能促进和改善骨髓的血流供应,可能有助于骨髓造血的恢复。更多还原

【Abstract】 Sublethally irradiated mice were immediatedly treated with 250mg/kg Ligustrazine phosphatis intraperitoneally twice a day for 7 days,and the bone marrow sections of ulna were observed.In the 5th day,the number of bone marrow mi- croveasel of the Ligustrazine group was much more than that of the control group.In the 7th day,the amount of the con- trol group had decreased to normal,while the Ligustrazine group was still increasing.Moreover,the microvessel area in Ligustrazine group was enlarged obviously.The percentage of the bone marrow hematopoietie tissue volume between the two groups had no significant difference in the first 7 days.But in the 7th day after irradiation,the percentage of the neu- trophilic granulocytes in peripheral blood increased in the Ligustrazine group.The results suggested that early use of Ligustrazine after acute radiation injury could promote and improve the blood supply of bone marrow,and may be helpful for recovery of bone marrow hematopoiesis.更多还原