【摘要】 本实验应用中药大黄提纯物大黄素干扰动脉粥样硬化加血管成形术后血管平滑肌细胞的生长增殖,发现大黄素具有明显的抑制平滑肌细胞增殖的作用,其机制可能是通过抑制细胞内血管紧张素Ⅱ生成,使其促细胞增殖的作用减弱。本实验为中药大黄在心血管病方面的开发应用提供了一定的理论基础。更多还原

【Abstract】 The effect of pure anthracene derivative Emodin,the major component of Rheum on smooth muscle cell proliferation following atherosclerosis and angioplasty were observed.The result showed that Emodin could markedly inhibit smooth muscle cell（SMC） proliferation,reduce the cell count by 32.15% in vitro.The mechanism may be that Emodin could in- hibit angiotensin-Ⅱ（AT Ⅱ）.In culture medium with 10^-5mg/ml Emodin in 2×10^-4SMC/ml,the AT Ⅱ level was 35. 6pg/ml,and in control 92.7pg/ml（P<0.01）.The inhibition rate was 61.60%.This preliminary experiment showed that Emodin may be a promising agent in the treatment of some cardiovascular diseases.更多还原