【摘要】 本文通过将Matrigel和MEM培养液分别作为人子宫内膜癌细胞悬浮液注射于裸鼠皮下，以及将子宫颈鳞癌活体组织用Matrigel浸泡后移植于裸鼠皮下，观察肿瘤形成的比较研究，了解Matrigel对人子宫癌分化、增殖的促进作用．结果表明，Matrigel可使人子宫癌细胞较快增殖，动物出瘤早、出瘤齐、生长快，并较好地保持肿瘤原有组织表型，是建立人瘤动物移植模型的一种良好试剂．更多还原

【Abstract】 The human endometrial adenocarcinoma cell line-Ishikawa cell suspended either in Ma-trigel or MEM buffered medium were injected subcutaneously into nude mice (N=10 mice/group);and fresh human cervical cancer tissues obtained directly from the surgery were coated by Matrigel and transplanted into nude mouse.The purpose of these studies was to see if Matrigel could enhance the human uterine cancers proliferation and differentiation in vivo.The results showed that when cancer cells or tissues implanted with Matrigel into nude mice,the xenografts could turn out earlier,proliferate faster and keep the original differentia-tion better.The conclusion is that Matrigel is a good agent for establishing animal models of human uterine cancer.更多还原