【摘要】 TNP-470是半合成的烟曲霉素类似物,具有较强的抗血管生成活性.为了验证其抗癌作用,本文将Walker256肉瘤细胞接种于Wistar大鼠皮下(2×10~7/鼠),将50只大鼠随机分成A、B、C、D E5组.第二天起分别给予生理盐水.TNP-470(30、50、100mg/kg)、CTX(30mg/kg)S.C.,q.o.d.第九天时,A、B、C、D、E各组皮下瘤重分别为3.88±1.24、2.20±0.58、1.64±0.25、0.86±0.30、1.17±0.33克.经统计学检验表明TNP-470能明显抑制Walker256肉瘤的生长,而且其抑制作用具有剂量相关性.对皮下肿瘤的病理研究发现:给TNP-470各组的肿瘤血管数目明显少于其他两组,而肿瘤坏死程度显著高于其他两组.该结果支持TNP-470通过抑制血管生成而抑制肿瘤生长更多还原

【Abstract】 TNP-470,a semisynthetic analogue of fumagillin has a potent antiangiogenesis effects. In order to test its anti-tumor effect, Walker 256 carcinoma cells(2×107/rat)were inoculated to 50 Wistar rats which were randomized into 5 groups. From the 2nd day.S. C. administration of NS (control), THP-470 (30, 50, 100mg/kg),CTX(30mg/kg)were given to each group.On the 9th day,the mean weight of the subcutanuous tumors of each group was 3. 88±1. 24,2. 20±0. 58,1.64±0. 25,0. 86±0. 30,1.17±0. 33(g) respectively,an anti-tumor effect of TNP-470 was clearly demonstrated in a dose dependent manner when analysized by Stu-dent-Newman-keuls test. Pathological study of the tumors showed that compared with the other 2 groups the number of tumor blood vessels was significantly decreased in TNP-470 treated groups;The extent of tumor necrosis was more severe in the former than the latter. These results suggest that the anti-tumor effect of TNP-470 was mediated by its anti-angiogenesis function.更多还原